The Japanese singer/artist, who is curating the event in June (13), has signed up acts including Patti Smith, Boy George, Marianne Faithfull, and Iggy and The Stooges for the festival's 20th anniversary.
Ono will also feature heavily in the line-up - she is kicking off the shows with her Plastic Ono Band at the Royal Festival Hall on opening night (14Jun13) and will wrap up the concerts with her finale, billed as Double Fantasy Live.
She will be joined by special guests to perform her and Lennon's Grammy-winning 1980 release Double Fantasy for fans in the U.K. capital.
Ono has also announced plans to host a special film programme at the Bfi, where she will screen rare movie footage she shot with Lennon.
The Beatles icon was fatally shot outside his New York City apartment three weeks after Double Fantasy hit shelves.