The Beverly Hills hitmaker will be the focus of new show DeTour, which he will also co-produce with his manager Dan Field.
The series, which has been picked up by Fox executives, will follow the fortunes of a 30-something rock star who walks away from the spotlight.
Cuomo, a big fan of Vipassana meditation, took his first sabbatical in 1995 so he could enrol at Harvard University. He completed his studies there more than a decade later. His latest hiatus came eight years ago.