The hip-hop star sparked fury among the chat show titan's fans earlier this week (begs18Nov13) after old video footage of him making lewd comments about Winfrey were leaked online.
In the video he dubbed the star an "ugly b**tch" before making a sexual reference, but now the No Hands hitmaker has spoken out to say sorry.
He tells Tmz.com, "I feel obligated to take responsibility for my actions and publicly apologize to Oprah. My remarks about you were both extremely unnecessary and disrespectful. This regretful situation made me look at women and how I address them in a more responsible way."
It's the latest controversy to hit the star, who is being sued along with his manager mother Debra Antney by fellow rapper Gucci Mane over claims of fraud. The rapper, who was also managed by Antney, alleges the pair released his music without permission and failed to pay him royalties.