He explained: "There's something very strong when the four of us walk into a building. I'm pretty famous so I'm used to walking into a room and having people look up, but when it's the four of us the hairs on their necks stand up.
"What they don't know is that is what's happening to us as well, which is really the bit that I'd still like to figure out."
The Irish rockers have been writing hits for over three decades, but Bono admits they have only just got used to their worldwide fame.
He said: "It has never felt less weird to be in U2. We've come out the end of a storm. The thunder and lightning that fame feels like when you're 20 turns out to be a little bit of inclement weather that's not really worth hiding indoors from.
"You realise you don't actually have to have your life turned upside down, you can have a family, and you don't have to end up in rehab. There are more interesting viruses to catch than the common cold called self-consciousness."