The superstar DJ is releasing a compilation record to raise money for anti-AIDS charity (RED), which was co-founded by the U2 rocker.
Tiesto said in a statement: ''When I went to Africa in 2006, I was struck by the devastating effect of AIDS.
''Now the world has an incredible chance to make sure that babies are born HIV-free by 2015, and the dance community is going to make a lot of noise to help make this happen.''
The album will be released on November 27, accompanied by a YouTube livestream of sets from Tiesto and other Dance (Red) artists from the Stereosonic Festival, which takes place in Melbourne, Australia, on World AIDS Day weekend on December 1 and 2.
(RED) CEO Deborah Dugan said: ''What Tiesto and his friends in the dance music community are bringing to this fight is invaluable.
''They bring the kind of heat that is so desperately needed to keep this issue at the top of the agenda.''