The former Velvet Underground frontman passed away five months after a liver transplant and the rock world has been stunned by the tragic news.
A post on The Who's official Twitter.com page reads: "R.I.P. Lou Reed. Walk on the peaceful side", while Frank Black and his Pixies bandmates add, "R.I.P. Lou Reed....A Legend."
Kings of Leon star Nathan Followill, British rocker Carl Barat, Justin Timberlake, Ryan Adams, Nile Rodgers, former My Chemical Romance star Gerard Way, The Black Keys drummer Patrick Carney and Sonic Youth's Lee Ranaldo also marked the sad news by taking to Twitter, while new mum Wood stated, "I am really bummed out today. Lost one of the greats."
Weezer also offered up their thoughts about Reed's passing, tweeting, "R.I.P Lou Reed - Vu (Velvet Underground) was a big influence when weezer was being formed, and (producer) Ric Ocasek told us cool stories of his friendship with him."
Meanwhile, rock historian Martin Lewis, who has produced an upcoming Dvd box-set of Amnesty International concerts that feature Lou Reed prominently, performing alongside Sting, Bono, Bryan Adams, Jackson Browne, Bruce Springsteen and others, tells Wenn, "Lou Reed was an exceptional pioneering musician who inspired both his contemporaries and those who followed after him.
"He generously supported Amnesty International from the very start of the Human Rights Concerts series, performing at all six concerts on Amnesty's A Conspiracy Of Hope U.S. tour in June, 1986. He recently very graciously gave his blessing for the release of those historic performances as part of Amnesty's Dvd box-set of the concerts.
"He was a remarkable musician and humanitarian. He will be greatly missed by everyone - including the human rights movement that he was passionate in supporting."