The Hate It or Love It hitmaker and Kardashian were exiting Tru Nightclub when the paparazzi swarmed around the pair, prompting the rap star to turn violent and threaten to destroy their equipment.
The Game, real name Jayceon Taylor, growled, "Put your cameras down, or there's gonna be seven broke cameras...
"You thought Kanye (west) was a problem? I'm a real problem... The next camera to raise to Khloe, I'ma (sic) break it, I'ma break u... that's y'all (sic) problem, y'all don't respect nobody."
He added, "If I ask somebody to put it down, put it down, that's my homegirl, sometimes y'all gotta (sic) respect people's s**t."
Fellow rapper West has had several run-ins with the paparazzi in recent months and was recently ordered to keep his distance from photographer Daniel Ramos, who he wrestled to the ground this summer (13), in an attempt to take his camera away during an altercation at Lax airport. He is facing battery and attempted grand theft charges and could serve up to a year behind bars if convicted.
Meanwhile, Kardashian has been all over the headlines in recent weeks following reports of a falling out and separation from husband Lamar Odom, who is allegedly seeking help for a drug abuse issue.