Ana Angel was working a shift at fast food chain Burger King when a blaze broke out in her mobile home in Tiffin, killing boyfriend Timothy Fresch and her five children, whose ages ranged from one to six.
The tragedy has moved the hip-hop superstars, who have offered up $20,000 (£13,000) each to help Angel pay for the funeral services.
The money will be donated through The Game's Robin Hood Project charity, with the producers of his reality Tv show Marrying The Game adding another $2,500 (£1,666).
The Game has taken to his Instagram page to open up about the fire tragedy, writing, "Repost from my brother Drake for helping in my donation of $22,500 to Ana Angel of Tiffin, Ohio on behalf of @therobinhoodproject."
He added: "I can deal with a lot of things but people losing their children is something that kills me every time."