The show will take place at Terminal 5 in New York on 25 November (13), with proceeds going to Doctors Without Borders.
The cast of Here Lies Love, the stage musical he wrote with Fatboy Slim about the life of former first lady of the Philippines, Imelda Marcos, will also perform at the event.
A statement from Byrne reads, "The show is about the resiliency of the Philippine people - it couldn't be more timely. Upon hearing about this tragedy, the cast contacted me about doing a show to raise money for relief efforts. Most of our cast is Filipino, and all of us feel the same way. It's personal for all of us."
In his e-mail newsletter, he further explains, "We'll be doing a concert version of the show - this won't be the same immersive, interactive experience as the theatrical version. But we'll do Every song, in order, with the original cast and costumes - plus I'll be helping out and singing as well. The show is wall-to-wall songs. If you didn't see or hear the production, now is your chance to hear it and at the same time to do something for the survivors in the Philippines..."
Byrne joins several other celebrities who are throwing their support behind relief efforts including Enrique Iglesias, who has urged fans to donate funds, and Black Eyed Peas star apl.de.ap, who performed at a charity event at the Xana Beach Club in Phuket, Thailand on Sunday (17Nov13). Proceeds were donated to the Filipino-born rapper's Give2Asia charity.
Typhoon Haiyan hit the Philippines on 8 November (13) and has killed almost 4,000 people to date (18Nov13). It is the second deadliest Philippine typhoon on record.