The 67-year-old actress fell for the singer when they worked on the movie 'The Hunger' together in 1983 but split up because she didn't want children.
She told the Daily Beast: ''I wasn't supposed to have kids and I'm the oldest of nine and had mothered all of them, so I wasn't ever in a mode where I was looking to settle down and raise a family, so that definitely changes the gene pool you're dipping into.''
However, Susan had nothing but praise for her former love.
She said: ''He's just a really interesting person, and so bright. He's a talent and a painter, and... he's great.''
Despite her reasons for splitting with David, 67, Susan gave birth to her first child, Eva Amurri, in 1985 with Italian filmmaker Franco Amurri.
She later had two sons with Tim Robbins, 55.
David and supermodel Iman, 59, married in 1992 and have a daughter together.
Susan also opened up about her past drug use, telling the publication: ''Yeah, I'm not new to the idea of mushrooms. I don't really like chemical things, really.
''Timothy Leary was a friend of mine, so that acid was nice and pure, but I'm not really looking for chemicals, and I don't like to feel speedy. But I've done Ayahuasca and I've done mushrooms and things like that.
''I like those drugs in the outdoors - I'm not a city-tripper. My attitude about marijuana or anything is, 'Don't be stoned if you have to pretend you're not,' so I'd never do drugs if I was taking care of my kids.''
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