Organiser Michael Eavis has let slip the two acts will perform at the world famous music event, which this year celebrates it's 40th anniversary, this summer.
Speaking at the Event Production Show at London's Olympia today (02.02.10), he revealed the 'Supermassive Black Hole' hitmakers will headline on Saturday June 26, while the legendary Motown singer is highly "probable" to top the bill on the closing night (27.06.10), in what will be his debut at the festival.
U2 are already confirmed as headliners for the Friday night (25.06.10).
However, Michael's daughter and co-organiser Emily Eavis admitted earlier this week a "festival virgin" would be headlining the final night.
She said: "We're pretty much sewn up now. We're still slightly confirming the Sunday night headliner but apart from that, we've pretty much finalised the Pyramid Stage which is good.
"It's a 40-year celebration this year so we've got some amazing highlights from the full 40 years and also some people who haven't played before, one headliner in particular, so we're very pleased with it.
"We're hoping to announce the names soon because I think there's an air of desperation and I understand that people want to know."
The festival takes place over the weekend of June 24-27 at Worthy Farm in Somerset, South West England.