The singer quit the group in 1998 following special performances at the Rock and Roll Hall of Fame, Grammy Awards and BRIT Awards.
Although MCVie has been spotted at Fleetwood Mac concerts in England, Nicks is adamant she will never return to the stage with her ex-bandmates.
She tells Rolling Stone magazine, "I would say there's no more a chance of that happening than an asteroid hitting the earth. She is done.
"You know when you look in somebody's face and you can just tell? She doesn't want to do it anymore. She doesn't want to fly. She doesn't want to come back to America. When she left, she left.
"She sold her house, her piano, her car. She went to England and she has never been back since 1998, so it's not really feasible, as much as we would all like to think that she'll just change her mind one day. I don't think it'll happen."