The 'Spider-Man: Turn off the Dark' show is set to open tonight (14.06.11).
The Broadway musical - which U2 frontman Bono and guitarist The Edge have written all the music and lyrics for - has been affected by months of turmoil including cast and crew alterations, story changes and injuries, following the first preview shows in November 2010.
'Spider-Man' - which stars Reeve Carney as Peter Parker/Spider-Man, Jennifer Damiano as Mary Jane Watson and Patrick Page as Norman Osborn/Green Goblin - has reportedly cost $65 million to create, making it the most expensive musical in history.
But it has been plagued by incidents, including one that saw stuntman Christopher Tierney end up in a critical condition in hospital after he fell almost 10 metres from a piece of scenery into an orchestra pit during a preview performance in December.
Bono has since referred to Christopher - who will return to the musical tonight - as a "rock star" due to his commitment to the project.
He told the USA Today newspaper: "Some real superheroes have emerged. I always feel like I'm pretending to be a rock star for a living. Chris Tierney is a rock star."
Other problems saw T.V. Carpio - who plays Arachne in the show - hurt her neck during a March performance after she had permanently replaced the original Arachne, Natalie Mendoza, who withdrew from the musical in December after suffering concussion during a preview performance in November.