The Stan hitmaker will take the controls for Don't Look Down, which is scheduled for release next year (13) - and he'll also feature on the project's first single C'mon Let Me Ride, according to Billboard.com.
Grey and Eminem previously worked together on Love The Way You Lie, for which the singer earned a Grammy nomination for Song of the Year.
Eminem says, "When I was working on (my album) Recovery I was introduced to Skylar and I was blown away with her talent as both a songwriter and vocalist. This album is really going to give her a chance to connect with the fans who probably know her music, but might not know her yet. I think they will be as impressed as I am."