The TV personality has responded to Gaga's claims that E! show 'Fashion Police' - which Kelly co-hosts - ''breeds negativity'', and has accused the 'Born This Way' singer of being a ''bully''.
The drama stems from Kelly's comments last October when she said, ''Lady Gaga's fans are the worst'' and accused them of encouraging her to commit suicide, she also claimed the pop superstar had a duty to step in and stop their comments.
In response, Gaga penned a lengthy open letter on her fan-based social networking site, LittleMonsters.com, addressed to the 'Fashion Police' star, noting that while she felt empathetic towards Kelly and discourages her fans ''from any negativity and violence'', she feels the E! show - which also features Joan Rivers - promotes bullying.
The Edge of Glory' hitmaker wrote: ''I have empathy for you Kelly, but I feel it culturally important to note that you have chosen a less compassionate path. Your work on E! with the 'Fashion Police' is rooted in criticism, judgement and rating people's beauty against one another. 'Appearance' is the most used reason for bullying in the world.
''Your show breeds negativity, and over the years has even become comedic in nature. It glorifies you and Joan Rivers pointing in the camera, laughing, and making jokes about artists and celebrities as if we are zoo animals.''
The letter prompted Kelly's mother Sharon to respond via her Facebook page, and revealed she had wrote to Gaga's manager to ask her fans to stop ''writing libellous, slanderous and vile comments about my family''.
She wrote: ''I don't feel I have to justify Kelly's choices in life to you. By your actions to Kelly right now, you have shown me that you are nothing more than a publicly (sic) seeking hypocrite and an attention seeker. You know it would have been much more dignified of you to do this privately. I am calling you a bully because you have 32 million followers hanging on your every word and you are criticising Kelly in your open letter. Are you so desperate that you needed to make this public?
Sharon added that ''a word from'' Gaga ''would stop all the hideous, negative and vile threats from your 'little monsters''', and stated she was open to continuing the debate should Gaga choose to.