Woodley picked up awards for Favorite Action Movie for Divergent and Favorite Movie Duo with onscreen love interest Theo James, while the actress' hit teen cancer film, The Fault in Our Stars, scored her the title of Favorite Dramatic Movie at the prizegiving in Los Angeles.
Lawrence landed two acting accolades - Favorite Movie Actress and Favorite Action Movie Actress.
Unfortunately, neither of the leading ladies were present at the Nokia Theatre to accept their awards.
Robert Downey, Jr. was another double winner, claiming the Favorite Movie Actor and Favorite Dramatic Movie Actor prizes, while Angelina Jolie's Maleficent was named Favorite Family Movie and Favorite Movie overall.
Long-running medical drama Grey's Anatomy earned the most trophies of the night, including Favorite Network Tv Drama, Favorite Dramatic Tv Actor and Actress for Patrick Dempsey and Ellen Pompeo, and former cast member Sandra Oh was named the Favorite Tv Character We Miss Most.
Other champions included Castle's Nathan Filion and Stana Katic (Favorite Crime Drama, Tv Actor and Actress) and British singer Ed Sheeran, who nabbed the Favorite Male Artist and Favorite Album titles.
Meanwhile, Ben Affleck was saluted as the Favorite Humanitarian for his work with the Eastern Congo Initiative, the organisation he set up in 2010 to help residents of the war-torn region.
Amy Adams presented her Batman v Superman: Dawn of Justice co-star Affleck with his prize, which he admitted was a trophy he never expected to receive.
He explained, "This is incredibly humbling... I've been called a lot of things in my life, but I'm not sure until recently humanitarian has ever been one of them. To be honest, it's something that I have a hard time accepting, because I've had the privilege of working alongside so many incredible people in Congo and all over the world, who I assure you are far more deserving."
Affleck continued, "Sometimes the world is a scary and terrible place and bad things happen... the one way to combat the terrible things we see is to bring a little bit of kindness and show that our country is about reaching out and helping our fellow man.
"This is an incredible honour - I can't say that I'm deserving, but I'm privileged to be among the many, many, many people who have done such great work."
Awards co-hosts Anna Faris and Allison Janney kicked off the show with a skit featuring Faris' husband Chris Pratt, who jokingly embellished his success after blockbuster movie Guardians of the Galaxy last summer (14), surrounded by piles of movie scripts as Faris attempted to convince him to take care of their young son, Jack.
Pratt actually missed the event because he was at home with the couple's son, who was recovering from eye surgery.
The full list of winners is as follows:
Favorite Movie - Maleficent
Favorite Movie Actor - Robert Downey, Jr.
Favorite Movie Actress - Jennifer Lawrence
Favorite Movie Duo - Shailene Woodley & Theo James (Divergent)
Favorite Action Movie - Divergent
Favorite Action Movie Actor - Chris Evans
Favorite Action Movie Actress - Jennifer Lawrence
Favorite Comedic Movie - 22 Jump Street
Favorite Comedic Movie Actor - Adam Sandler
Favorite Comedic Movie Actress - Melissa MCCarthy
Favorite Dramatic Movie - The Fault in Our Stars
Favorite Dramatic Movie Actor - Robert Downey, Jr.
Favorite Dramatic Movie Actress - Chloe Grace Moretz
Favorite Family Movie - Maleficent
Favorite Thriller Movie - Gone Girl
Favorite Tv Show - The Big Bang Theory
Favorite Network Tv Comedy - The Big Bang Theory
Favorite Comedic Tv Actor - Chris Colfer (Glee)
Favorite Comedic Tv Actress - Kaley Cuoco-Sweeting (The Big Bang Theory)
Favorite Network Tv Drama - Grey's Anatomy
Favorite Dramatic Tv Actor - Patrick Dempsey (Grey's Anatomy)
Favorite Dramatic Tv Actress - Ellen Pompeo (Grey's Anatomy)
Favorite Cable Tv Comedy - Melissa & Joey
Favorite Cable Tv Drama - Pretty Little Liars
Favorite Cable Tv Actor - Matt Bomer (White Collar)
Favorite Cable Tv Actress - Angie Harmon (Rizzoli & Isles)
Favorite Tv Crime Drama - Castle
Favorite Crime Drama Tv Actor - Nathan Fillion (Castle)
Favorite Crime Drama Tv Actress - Stana Katic (Castle)
Favorite Network Sci-Fi/Fantasy Tv Show - Beauty and the Beast
Favorite Cable Sci-Fi/Fantasy Tv show - Outlander
Favorite Sci-Fi-Fantasy Tv Actor - Misha Collins (Supernatural)
Favorite Sci-Fi/Fantasy Tv Actress - Kristin Kreuk (Beauty and the Beast)
Favorite Competition Tv Show - The Voice
Favorite Daytime Tv Host - Ellen DeGeneres
Favorite Late Night Talk Show Host - Jimmy Fallon
Favorite Dramedy - Orange Is The New Black
Favorite Tv Icon - Betty White
Favorite Tv Duo - Nina Dobrev and Ian Somerhalder (The Vampire Diaries)
Favorite Tv Character We Miss Most - Dr. Cristina Yang played by Sandra Oh (Grey's Anatomy)
Favorite Actor In A New Tv Series - David Tennant (Gracepoint)
Favorite Actress In A New Tv Series - Viola Davis (How to Get Away With Murder)
Favorite Sketch Comedy Tv Show - Saturday Night Live
Favorite Animated Tv Show - The Simpsons
Favorite New Tv Comedy - Jane the Virgin
Favorite New Tv Drama - The Flash
Favorite Male Artist - Ed Sheeran
Favorite Female Artist - Taylor Swift
Favorite Group - Maroon 5
Favorite Breakout Artist - 5 Seconds of Summer
Favorite Male Country Artist - Hunter Hayes
Favorite Female Country Artist - Carrie Underwood
Favorite Country Group - Lady Antebellum
Favorite Pop Artist - Taylor Swift
Favorite Hip-Hop Artist - Iggy Azalea
Favorite R&B Artist - Pharrell Williams
Favorite Album - X by Ed Sheeran
Favorite Song - Shake It Off by Taylor Swift
Favorite Humanitarian - Ben Affleck.
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