The 'Les Miserables' actress and the 33-year-old model enjoyed a brief romance earlier this summer but David - who has previously dated TV presenter Laura Whitmore and The Saturdays singer Mollie King - insists he is single.
He told the Mail On Sunday newspaper: ''I am single at the moment.
''This summer I am going to Los Angeles and then New York. Samantha's gone to LA now and if I see her in LA then I see her in LA . . .
''I am not going to go out of my way to see her, but if I bump into her, I bump into her.''
However, Samantha, 22, isn't short of male admirers with renowned lothario Russell Brand recently revealing he had a crush on her.
The comedian - who was previously married to Katy Perry - took a shine to the actress after he spent most of the post-Oscars Vanity Fair party in Los Angeles in February flirting with the ''bedimpled angel''.
He said: ''So many ladies caught my eye; it was like an assault on the senses. But I like that girl from 'Les Miserables', Samantha. We chatted and she's from the Isle of Man.
''She's like a bedimpled, little Manx angel. She was a lovely, beautiful young woman.''
Without giving away any spoilers, both the British actors hinted that season seven of 'Game of Thrones' would be eventful, shall we say.
Depp cut the first installment of cheques in his divorce from Amber Heard, sending them directly to the charities she named.
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