The veteran singer is said to have ended his relationship with Amanda Sheppard less than two years after they exchanged vows.
Sheppard, who is 37 years younger than the 67-year-old star, moved out of the couple's marital home after a series of arguments.
A source tells British newspaper The Sun, "They haven't seen eye-to-eye for a long time and drifted apart. It made sense for Amanda to move out and think about starting a new life without Bryan."
The couple wed in a private ceremony at a luxury resort on the Turks and Caicos Islands in January 2012.
Before their wedding, Ferry admitted he felt lucky to have found love with a younger woman, insisting, "The interesting thing is - and I don't want to say the wrong thing in case I get into trouble with my girlfriend - you never really meet people your own age who aren't married. I'm very fortunate that I work in music, where you're in touch with different age groups, either the audience or people you work with. It does help. Obviously I'm not ageist!"
Ferry began dating Sheppard in 2008 following his split from Katie Turner earlier that year. He was married to Lucy Helmore from 1982 until their divorce in 2003.