The Pink Floyd rocker, 73, has long campaigned against the Israeli government due to their actions in the conflict over Palestinian statehood and recently called on British dance duo the Chemical Brothers to cancel a concert in the country.
Regina, 36, who spent her early childhood in the Soviet Union before moving with her parents to America aged nine, strongly disagrees with Roger's view that artists should boycott the Jewish state.
"He's a great artist, but I don't agree with him politically," She tells British newspaper The Times. "There are so many people who are not into the politics of Israel and (those politics) have nothing to do with the people who come to these concerts."
The You've Got Time singer will not join musicians including Nick Jonas, Demi Lovato and Bruce Springsteen in refusing to play in North Carolina due to the state's controversial anti-transgender "bathroom bill" for the same reason.
"I'm not going to say I won't play North Carolina because they have these f**ked up anti-gay laws, " she explains. "Who am I going to punish? The progressive people that were going to come. By not playing in Israel you're punishing the wrong people."
Earlier this month (Nov16) Roger signed an open letter calling on the Chemical Brothers to cancel their concert in the Israeli city of Tel Aviv which read, "When international artists, such as the Chemical Brothers, perform at Israeli cultural venues and institutions, they help to create the false impression that Israel is a ‘normal’ country just like any other.”
The concert went ahead as planned on 12 November (16).