The event has enjoyed almost three decades of success in the U.K. as part of the nation's annual Comic Relief charity push - raising over $1 billion since its inception in 1988 - but Thursday's event was the first of its kind in the U.S.

Co-host Seth Meyers kicked off the three-hour telecast by explaining the goals for the night, and joked, "We have one goal and one goal only - raise enough money to shove this in England's stuck-up face. Oh and also to raise money for kids in need."

The comedy continued with a sketch which featured Meyers calling on actor Chris Pine to help out with Red Nose Day, which will benefit 12 charity organisations fighting poverty in the U.S., Africa, Asia and Latin America.

Pine received a call from his Into the Woods co-star Emily Blunt, and after the two broke out in song, he asked her to join him for a fundraiser called Red Rose Day.

The game of telephone continued as Blunt's husband John Krasinski, Zac Efron, Neil Patrick Harris, Sean 'Diddy' Combs, Jennifer Aniston, Matt LeBlanc and Jennifer Garner all misinterpreted the name of the telethon and its goal.

The conversation ended with Reese Witherspoon calling Meyers back, requesting his assistance for a fundraiser called, "the day they stopped making rose (wine)", which benefits "animals with alcoholism".

More stars including Olivia Wilde, Coldplay, Will Ferrell, Jack Black, Adam Levine, and Blake Shelton are scheduled to appear during the telethon.