The legendary rockers are the first act to be confirmed to play at the prestigious event in Belfast, Northern Ireland, on November 6 and they can't contain their excitement.
The band said in a statement: "We haven't played in Belfast in a long time, so we're really looking forward to performing at the '2011 MTV EMA' and seeing all our fans!"
As well as announcing the Red Hot Chili Peppers' involvement, MTV have also revealed that for the first time the EMAs will be presented from three locations throughout the show's host city.
Belfast's Odyssey Arena will serve as the main stage, with the two other locations in the city to be announced in the coming weeks.
Bruce Gillmer, Executive Vice President of Talent and Music Programming/Events for Viacom International Media Networks said: "We're really excited to celebrate Belfast and its rich musical heritage by showcasing MTV EMA performances from multiple sites throughout the city. These three stages will give fans a unique and unprecedented opportunity to experience the live music of the EMA."
The awards will be hosted by singer-and-actress Selena Gomez.