The rocker, 44, sat down with his Atoms for Peace bandmate Nigel Godrich to answer questions submitted by young readers as part of the Ask a Grown Man blog spot on RookieMag.com.
Yorke first responded to a 16-year-old girl from Vermont, who asked him for tips on how to overcome her nerves and approach a boy she likes.
He said, "If you have a crush on him, if you're really, really, really, really shy, which is what I was when I was that age - also, I was at a boys' school so it was impossible to meet girls anyway - how about just write him a note?... Or throw him against the wall sometime."
Another teen admitted she feels insecure about a scar on her chest, and Yorke opens up about his own physical flaw, a lazy eye that was completely shut when he was born.
He explains, "When I was your age, I was convinced that girls would think that (my eye) was really not very nice at all. I worked in this pub and this old woman - she was so funny - she used to come in all the time. And she was the first person who really said to me, 'It's the nicest thing about you.'
"She was p**sed (drunk) all the time, but I went with it. You'd be surprised. You know, everyone is imperfect. No one has a symmetrical face. No one's body is perfect. Don't worry."
Filmmaker Judd Apatow and actors Jon Hamm and Paul Rudd have also filmed installments for the Ask a Grown Man series.