The Chelsea Lately star was a guest on Piers Morgan Live and the chat turned into a war-of-words after Handler criticised the former tabloid editor's interviewing skills.
The blonde funnywoman, who interviews guests on her own talk show, told the host, "You can't even pay attention for 60 seconds. You're a terrible interviewer," promoting Morgan to retort, "Well you just weren't keeping my attention... What is your problem?"
The exchange became heated as Handler fought back, adding, "That's not my problem... This is your show. You have to pay attention to the guests that you invited on your show... It doesn't matter how interesting I am. You signed up for this job."
Handler then took a swipe at Morgan's show, which is going off-air soon after being axed by network bosses, adding, "Maybe that's why your job is coming to an end," prompting Morgan to exclaim, "Wow!".
After the interview, Morgan sent Handler a message via Twitter.com, adding, "If I'm such a 'terrible interviewer'... how come everyone's now tweeting & debating our interview... mwah x."