The 'What Makes You Beautiful' hitmakers - consisting of Niall Horan, Zayn Malik, Liam Payne, Harry Styles and Louis Tomlinson - will battle against Harry's former girlfriend for Favourite Song at this year's awards, while the band are also up for Favourite Musical Group.
Harry, 19, told People magazine: ''We are delighted with our nominations for the Kids' Choice Awards. It was amazing to perform 'What Makes You Beautiful' at last year's show. Thank you as always to our incredible fans and supporters!''
One Direction will also face competition from Big Time Rush, Bon Jovi and Maroon 5 to earn the title of Favourite Musical Group.
Elsewhere, 'Wizards of Waverly Place' actress Selena Gomez is nominated for Favourite TV Actress and 'America's Got Talent', 'American Idol', 'The Voice' and 'Wipeout' will vie for Favourite Reality Show.
The full nominations for this year's Kids' Choice Awards will be announced later today, with voting due to begin on Thursday (14.02.13).
The ceremony takes place on March 23 at the University of Southern California's Galen Center, and will be hosted by 'Transformers' actor Josh Duhamel.
Partial nominees list:
Favourite Musical Group:
Big Time Rush
Carly Rae Jepsen, 'Call Me Maybe'
One Direction, 'What Makes You Beautiful'
PSY, 'Gangnam Style'
Taylor Swift, 'We Are Never Ever Getting Back Together'
Favourite TV Show:
'Good Luck Charlie'
'Wizards of Waverly Place'
Favourite TV Actor:
Carlos Pena, 'Big Time Rush'
Jake T. Austin, 'Wizards of Waverly Place'
Lucas Cruikshank, 'Marvin Marvin'
Ross Lynch, 'Austin & Ally'
Favourite TV Actress:
Bridgit Mendler, 'Good Luck Charlie'
Miranda Cosgrove, 'iCarly'
Selena Gomez, 'Wizards of Waverly Place'
Victoria Justice, 'Victorious'
Favourite Reality Show:
'America's Got Talent'