The legendary artist gave the heart picture to the Duran Duran star and supermodel Julie Anne Rhodes after they exchanged vows in 1984.
The couple divorced in the 1990s, and Julie Anne decided to sell it off this week (beg10Nov14) to raise money for a business venture.
The silkscreen, which features a personal inscription from Warhol on the back, sold for $149,000 (£93,125) at Christie's auction house in New York on Thursday (13Nov14).
Julie Anne tells Dailymail.co.uk, "I feel a little bit emotional - and I wasn't expecting to feel so attached to a thing. It's like saying goodbye to Andy all over again... Nick is aware I am selling it. I think he might be a little bit upset but he didn't have much say in the matter. He kept most of the (art) collection we amassed together but there were a couple of little pieces I wanted to hang onto until now."
Warhol died in 1987.