San Diego's annual Comic-Con celebration kicked off on a sombre note on Tuesday (10Jul12) when a Twilight fan was killed outside the city's Convention Center.
The 53 year old, identified as Gisela G, was crossing a road to get in line for Thursday's (12Jul12) Breaking Dawn - Part 2 panel discussion when she was hit by a car.
She died from her injuries, according to local reports, which indicate the tragic fan was unconscious and "bleeding profusely" when paramedics raced her a nearby hospital.
Twilight fans who witnessed the tragedy have flooded Gisela's with notes of condolence.
Comic-Con 2012, the world's largest convention of comic book and sci-fi and fantasy fans, officially opens on Thursday.