The 46-year-old rapper has recruited the former Destiny's Child star and the 45-year-old hip-hop legend for the new song, with the title yet to be revealed.
Sharing the artwork for the track on Twitter, Mary wrote: ''BRAND NEW BUSTA MISSY KELLY DROPPING TOMORROW NIGHT AT MIDNIGHT!! 2.2.18 IT'S TIME!! (sic)''
It will be the first new music from Kelly since she featured with singer/songwriter Jacob Whitesides on 'I Know What You Did Last Summer' in 2015.
The 'Dilemma' hitmaker previously teased she will be releasing more solo music this year.
She said: ''2018 new music. What I'm excited about [fans] most to hear is probably stories I've never told on this album. I haven't released a record in five years.''
As for Missy and Busta they recently collaborated on a sponsored commercial for the Super Bowl for Doritos and Mountain Dew.
The pair have previously released six songs together, including 1998's 'Get Contact' and 2008's 'She's Fine'.
And Kelly and Missy have also worked together before, they featured on R&B star Fantasia's 2013 track 'Without Me'.
Missy continues to be prolific in releasing new music, last year she dropped 'I'm Better' with Lamb, and the year before she teamed up with Fall Out Boy for the 'Ghostbusters' soundtrack, 'Ghostbusters (I'm Not Afraid)'.
Janelle Monáe parties and drives with her girl squad in the video for her latest single 'Crazy, Classic, Life', taken from her album 'Dirty...
Continuing the softer sound of their 2015 release 'That's the Spirit', BMTH are about to release 'Amo' (January 25th 2019) featuring their newest...
To coincide with the new BBC mini-series adaptation of leporine epic Watership Down, Sam Smith has unveiled a new single entitled 'Fire on Fire'.
Her first single since leaving the jungle on 'I'm a Celebrity... Get Me Out of Here!', Fleur East drops the super-choreographed video for 'Favourite...
Dropping the video for his latest album's second single, 'Excuses', is Olly Murs just months after the release of 'Moves' featuring Snoop Dogg.
Professor Green and Rag'n'Bone Man have teamed up for a heart-wrenching video for their single 'Photographs'.
He released 'Everythang's Corrupt' last month, and now Ice Cube has dropped a video for the record's third single 'That New Funkadelic'.
Dappy has unveiled a new stripped down number entitled 'Count On Me' more than six years after the release of his debut solo album.
Somehow the people at Universal Pictures got it into their heads that easy-on-the-eyes, thin-on-talent Jessica...
Is anybody else getting tired of doofus dad comedies? I don't know about you, but...