Dr. Conrad Murray's lawyers have claimed Michael Jackson "caused his own death".

During their opening statement of the trail, his defence team claim the medic - who has been accused of administering the lethal dose of the anaesthetic Propofol that killed the 'Thriller' singer on June 25 2009 - was concerned about how much knowledge the 'Beat It' hitmaker had of Propofol.

Attorney Ed Chernoff told the jury at a Los Angeles courthouse: "During the 10 hours on June 25, 2009, while Michel Jackson was frustrated because he could not sleep, frustrated because his doctor refused to give him a drug that he preferred, that he wanted, he did an act without his doctor's knowledge, without his doctor's permission, against his orders - he did an act that caused his own death.

"The science will show you that Michael Jackson swallowed eight, 2 mg Lorazepam pills. ... He did this when Dr. Murray was not around. ... When Dr. Murray left the room, Michael Jackson self-administered a dose of Propofol ... that created a perfect storm in his body that killed him instantly.

"There was no doctor ... No Machine that was going to revive Michael Jackson. He died so rapidly, so instantly - he didn't even have time to close his eyes. ... We will provide to you the science to show you what happened."

Murray could face four years in prison if he is found guilty.