The Bridesmaids star joined the likes of Robert De Niro, Julianna Margulies, and Tracee Ellis Ross at the Harlem Armory, where the celebrities joined Mrs. Obama in congratulating the 4,000 students in attendance for scoring admission to college.

The National College Signing Day 2016 event, held in partnership with bosses at MTV, also featured a performance by singer Alessia Cara, while New York Knicks basketball star Carmelo Anthony also took the stage, telling the youngsters, "College is fun, take advantage of the opportunity."

Melissa and her husband, filmmaker Ben Falcone, were then given the job of introducing the crowd to the First Lady, who stepped out to great applause as she proudly wore a T-shirt bearing the name of her alma mater, New Jersey's Princeton University.

"We're here to celebrate you!" she told the crowd at the third annual event. "We all know that completing your education past high school is the most important thing you can do to reach your dreams."

She later added, "The minute you get to college this fall, I want you to get back to work. The goal is to get that degree!"

Other star guests at National College Signing Day 2016 included hip-hop pioneer Joseph 'Rev. Run' Simmons, actress Allison Williams, Glee singer/actor Darren Criss, Supergirl Melissa Benoist, and child star Bailee Madison, among many others.

Girls star Allison took to social media after the bash to share a photo of herself at the event.

"What an unbelievable afternoon with about 4,000 high school students, and 1 incomparable FLOTUS (@michelleobama) #CollegeSigningDay," she captioned the image.

Melissa McCarthy also posted pictures on her Instagram page, writing alongside a picture of her and her husband, "Such an an amazing experience today."