Motorboat will set sail to Key West, Florida and Cozumel, Mexico from Miami in September (14).
Dubbed "the loudest boat in the world", the cruise will also feature performances by Zakk Wylde, Danko Jones and Fireball Ministry.
Motorhead founder Lemmy Kilmister says, "This will be everything you've come to expect from a night out with us, except even louder, with more great bands and no way of escaping! If you thought waves could rock a boat, you've got another thing coming with this lovely little outing!"
Megadeth's Dave Mustaine adds, "There never has and never will be another cruise like Motorboat cruise. Come on a thrashing voyage with Motorhead, Megadeth, Anthrax, Zakk Wylde and all Lemmy's friends. This is the coolest way to ever see a metal concert."