The hip-hop star was booked to headline the Start Up Rock On concert in Washington, D.C. to mark Obama's re-election, but he used his set to voice his frustration with the current administration.
Fans at The Hamilton venue were stunned as Fiasco performed an anti-Obama song for 30 minutes, and reportedly refused to move on to another track.
Josh Rogin, a reporter for news website The Cable, took to Twitter.com to describe the incident, writing, "Lupe Fiasco just got thrown off stage here at the Hamilton Live after he went on an anti-Obama diatribe mid set."
Rogin added, "Lupe played one anti-war song for 30 min and said he didn't vote for Obama and eventually was told to move on to the next song. Lupe refused to move to the next song so a team of security guards came on stage and told him to go."
Matt Dornic, senior director of public relations for CNN, also tweeted, "Things going terribly wrong at Lupe Fiasco performance during Suro. Kicked off stage, bashing Obama."
It's not the first time Fiasco has openly criticised the president - he hit headlines in 2011 after taking aim at Obama's foreign policy stance and branded him a terrorist.