The pair's remix featuring Justin Bieber picked up Record Of The Year, Song Of The Year, Best Urban Fusion Performance and Short Form Music Video at the ceremony held at Las Vegas' MGM Grand Garden Arena on Thursday night (16.11.17).
Speaking to 'Entertainment Tonight' about his nominations before the ceremony, Luis - who was joined at the star-studded bash with his wife Agueda Lopez - said: ''The Latin GRAMMYs to me are the most important music award for Latin music and to have four nominations is certainly an honour.
''To have Record of the Year and Song of the Year nominations are two huge categories, those two have a lot of weight.
''But, you can't control whether you win or lose and all the artists that are nominated are amazing, so I'm really just truly blessed to be among a great group of artists that I admire.''
Shakira - who was recently forced to axe the European leg of her 'El Dorado World Tour' due to a vocal haemorrhage - picked up Best Contemporary Pop Vocal Album for 'El Dorado'.
Whilst Lin-Manuel Miranda was the recipient of the President's Merit Award for his contribution to Latin music and helping with the relief teams in Puerto Rico following Hurricane Maria.
The American composer - the creator of the 'Hamilton' musical - dedicated the accolade to his wife Vanessa Nadal.
Speaking on stage, he said: ''My people! Thank you, it's an honour to be here.
''No one gets here alone.
''I know I'm a weird theatre kid here, with a weird accent.
''But let's keep collaborating and show the world that Latinos can change the world when we collaborate.''
The 2017 Latin Grammy winners list is as follows:
Album Of The Year:
Salsa Big Band -- Rubén Blades and Roberto Delgado & Orquesta
Record Of The Year:
'Despacito' -- Luis Fonsi featuring Daddy Yankee
Song Of The Year (A Songwriter's Award):
'Despacito' -- Daddy Yankee, Erika Ender and Luis Fonsi, songwriters (Luis Fonsi featuring Daddy Yankee) songwriters (Ricky Martin featuring Maluma)
Best New Artist:
Best Contemporary Pop Vocal Album
'El Dorado' -- Shakira
Best Urban Fusion / Performance:
'Despacito' (Remix) -- Luis Fonsi and Daddy Yankee featuring Justin Bieber
Best Traditional Pop Vocal Album:
Salón, Lágrimas y Deso--Lila Downs
Best Urban Album:
Best Urban Song:
''Somos Anormales''--Rafael Arcaute, Igor Koshkendey & Residente, Songwriters (Residente)
Best Alternative Music Album:
Jei Beibi -- Café Tacvba
Best Alternative Song:
'Amárrame' --Mon Laferte, Songwriter (Mon Laferte feat. Juanes)
Best Rock Album:
La Gran Oscilación--Diamante Eléctrico
Best Pop/Rock Album:
Mis Planes son Amarte--Juanes
Best Rock Song: (TIE)
'Déjala Rodar' --Diamante Eléctrico, Songwriters (Diamante Eléctrico)
'La Noche' --Andrés Calamaro, Songwriter (Andrés Calamaro)
Best Regional Song (A Songwriter's Award):
'Siempre Es Así' -- Juan Treviño, songwriter (Juan Treviño featuring AJ Castillo)
Best Salsa Album:
Salsa Big Band--Rubén Blades Con Roberto Delgado & Orquesta
Ni Un Paso Atrás--Jorge Celedón Y Sergio Luis Rodríguez
Best Contemporary Tropical Album:
Best MPB (Música Popular Brasileira) Album:
Dos Navegantes -- Edu Lobo, Romero Lubambo, and Mauro Senise
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