The How to Get Away with Murder actress filed for divorce from Paul recently after they separated in January (16), according to documents obtained by TMZ.com.
In the legal papers, Liza is requesting joint custody of their five-year-old daughter and they are deciding the details of spousal support in private mediation.
Liza and Paul, who have both starred in TV mogul Shonda Rhimes' hit shows Grey's Anatomy, Scandal and Private Practice, wed in 2006.
The former Gilmore Girls star told the show's fan podcast in September (15) she never imagined tying the knot with someone in showbusiness, explaining, "I think both of us didn't think that we would marry another actor, because it's hard."
She continued, "If you just have the other idea of another one of you, you don't really want to wake up next to you in the morning. But we're both very different and similar in terms of how we work, so it works for us. It's really nice to have that built-in shorthand and understanding. It's not for everyone though. I think we're very well matched."
The news comes weeks after Liza's How to Get Away with Murder co-star Charlie Weber filed for divorce nine months after marrying his girlfriend Giselle.