The Lollipop hitmaker, a known weed advocate, was booked as the headliner for the High Times publication's Cannabis Concentrates Cup show in San Bernardino, hitting the stage after fellow hip-hop star B.o.B.

However, Wayne performed just four songs before vowing never to return to the drug-filled event, dropping the microphone as he made a quick exit.

"Don't you ever, ever, ever ask me to do this s**t again!" he fumed as he cut short his set, reports TMZ.com.

It's not clear what angered Wayne and prompted him to leave the gig early, but rumours suggest he was upset at the audience's lack of energy as attendees battled dehydration and soaring temperatures inside the venue.

Organisers at High Times have also been left stunned by Wayne's behaviour and have since issued a statement addressing the incident.

It reads: "We have no idea why, after a stellar performance by B.o.B, Lil Wayne suddenly ended his performance after just four songs when he was contractually committed to performing for an hour for the fans.

"We are truly baffled by why Lil Wayne would do this in front of thousands of Cannabis Cup attendees - in total disregard for his fans - and are awaiting an explanation from his team."

Representatives for Wayne have yet to publicly comment on the shortened show, where attendees were required to have state-issued medical marijuana cards, allowing them to legally purchase pot.