The professional basketball player will star in the hotly-anticipated Warner Bros. movie - a follow up to the live-action 1996 original, which featured Michael Jordan - and he is delighted to be working with the 'Black Panther' director on the project.
He said: ''The 'Space Jam' collaboration is so much more than just me and the Looney Tunes getting together and doing this movie.
''It's so much bigger. I'd just love for kids to understand how empowered they can feel and how empowered they can be if they don't just give up on their dreams. And I think Ryan did that for a lot of people.''
Coogler will produce 'Space Jam 2', and James is excited about what he will bring to the movie.
He added to The Hollywood Reporter: ''I loved his vision [for 'Black Panther']. So for Ryan to be able to bring that to kids, it's amazing.''
Terence Nance will direct the motion picture, which is expected to be released next year, and Justin Lin - who was initially directing the film but pulled out - will remain on board as executive producer.
The original 'Space Jam' film saw Jordan team up with Bugs Bunny and the rest of the 'Looney Tunes' cartoon characters to play a game of basketball to save them from enslavement at an alien amusement park.
'Space Jam 2' will be James' first big movie role since he appeared alongside Amy Schumer in 2015 comedy film 'Trainwreck'.
Schumer - who also starred alongside Bill Hader in the hit motion picture - confessed: ''I wrote him in [the movie] because he's the only basketball player I've ever heard of.''
James - who recently signed a huge contract with the Los Angeles Lakers franchise - has been tipped to star in another comedy movie after screenwriter Steve Mallory sold a script to Paramount Players.
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