Kris Jenner has spoken out against her sisters adultery accusations.

The 'Keeping Up With The Kardashians' star insists she is no longer in touch with her sister Karen Houghton, who accused her of having affair during her 22-year marriage to Bruce Jenner, following news the couple who have daughters Kendall, 17, and Kylie,16, together have separated.

Kris told RadarOnline: ''Unfortunately, my sister has been dealing with demons for years. I am not in touch with her but I wish her the very best.''

Sources claim the siblings haven't seen each other for nearly a year and Karen has no real knowledge about Kris' personal life.

A source revealed: ''The reality is that Karen and Kris have not had a discussion about Kris' private life for 28 years. She has no knowledge of Kris' family life or her husband, except what she sees on the show. And she has used this to create a fanciful tale of what is going on inside the family.''

Karen has a tendency to be angry and jealous and perhaps this was her motivation to go on the media tour.''

Karen had also suggested earlier this month she had witnessed Khloe Kardashian's husband, Lamar Odom in an incoherent state during a family dinner as a result of his alleged cocaine addiction.