The 33-year-old reality star was recently faced with a tough decision when her boyfriend Tristan Thompson was accused of cheating on her just days before she gave birth to their daughter True, now three months.
Khloe opted to stay with Tristan, and her older sister Kim - who has North, five, Saint, two, and Chicago, six months, with her husband Kanye West - has said the whole family are on board with her decision, as long as she's happy.
Kim said: ''It was definitely new territory for us when you have a new baby coming into the world. I think ultimately, we always want her to be happy, but it gets all clouded when there's a baby, you know?
''Her motherly instincts kicked in and she has to do what makes her happy. So we'll support that.''
The 37-year-old star also teased that some of Khloe's drama is detailed on the upcoming season of their reality show 'Keeping Up with the Kardashians' - which premieres on Sunday (05.08.18) - but notes that Khloe was keen to keep her privacy whilst she confronted Tristan in Cleveland.
Speaking to 'On Air with Ryan Seacrest', she added: ''I don't want to give too much away, because we genuinely had those conversations and sometimes we were filming and sometimes we weren't. It was more maybe when Khloé wanted her privacy and no cameras when she was in Cleveland going through that, [but] the sisters were still all filming and talking [about] how to approach it and what to do.''
Kim has previously been vocal about her sister's situation, previously calling it ''so f***ed up''.
She said: ''I don't even know how to describe it besides it's just so f***ked up.
''Poor Khloe. We really were rooting for Khloe and we still are. She's so strong and she's doing the best that she can.
''It's a really sad situation all over. I kind of made this rule with my brother that if there's a baby involved, I'm going to keep it cute and classy and try not to say anything negative because one day True is going to see this.
''It's just so messed up.''
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