Khloe Kardashian misses her brother and ''best friend''.

The 'Keeping Up with the Kardashians' star shared a picture of herself and sibling Rob Kardashian - who is said to have distanced himself from his family in recent weeks - as children on her Instagram page but the sock designer didn't respond to her comments.

Khloe wrote alongside the picture:''I miss my best friend @robkardashian (sic)''.

Instead, Rob - who used to live with Khloe and her estranged husband Lamar Odom - began retweeting messages of support from his fans.

One wrote: ''@robkardashian is the most down-to-earth and likeable member of the Kardashian klan. Chin up, and f**k everyone who says otherwise. (sic)''

Rob missed his other sister Kim Kardashian's recent wedding to Kanye West, reportedly because he was unhappy with his weight gain and appearance, but his mother Kris Jenner says he is now focused on looking after himself.

She said: ''Rob is working on himself. He's going to be OK. A lot of prayer and, you know, he's such a great human being...he's my heart.''

It was recently claimed Rob is so determined to distance himself from his famous family, he has asked not to be given any storylines in the next series of 'Keeping Up with the Kardashians' and only wants a minimal role on the show.