The 27-year-old reality star - who with husband Lamar Odom enjoyed a double-date with the fledgling couple in New York last weekend - revealed things between her older sibling and the 'Gold Digger' rapper are only just getting off the ground.
Appearing on US show 'Watch What Happens Live', she said: ''I don't think it's serious. I think it's too soon. But because they've been friends for so long, it's just so easy and that's something I love seeing for Kim - the easiness and how happy she is. And it's just more of a great Friendship and friendships make the best relationships.
''We've known Kanye for like nine years. He's great with the family, but again we've known him for so long. It's not like some stranger getting into a hurricane.''
Kim, 31, married basketball star Kris Humphries last August but filed for divorce after just 72-days of marriage, and Khloe admits she didn't have such a soft spot for the NBA star, who she says ''rubbed her the wrong way''.
She previously explained: ''When I met Kris the very first time, I had just landed in New York and it was late at night.
''One of the first things that came out of his mouth - like within the first five minutes - was, 'So, how much you getting paid to fake your marriage? Like how long are you gonna keep this up for?' And I was like, 'Okay, dude, I don't know if you're trying to make me laugh ... But he just rubbed me the wrong way.
''So ever since then I had a very defensive wall brought up. I'm a very good judge of character, if I do say so myself.''