The 'Tik Tok' singer was thrilled with her prize but Lady GaGa was the big winner receiving an impressive three trophies at the prestigious ceremony, including Best Pop, Best Female and Best Song for 'Bad Romance'.
Gaga - who was nominated for five accolades - did not attend the ceremony but accepted her statuettes via satellite from Budapest where she was performing on her smash hit 'Monster Ball Tour'.
Katy Perry - who picked up the accolade for Best Video for 'California Gurls' - and her new husband Russell Brand made their first official appearance as a married couple following their wedding in India last month.
Other winners on the night included Thirty Seconds to Mars who got the Best Rock prize, Best Hip-Hop went to Eminem, Paramore were victorious in the Best Alternative category, while Linkin Park were named Best Live Act.
Colombian singer Shakira was presented with the Free Your Mind award in recognition of her charity work and commitment and dedication to making education accessible for children around the world.
The 2010 awards closed with a rock medley from inaugural MTV EMA Global Icons Bon Jovi, featuring a trio of hits including their most recent hit single 'What Do You Got?' along with 'You Give Love A Bad Name' and 'It's My Life'.
The MTV European Music Awards 2010 full list of winners:
Best New Act: Kesha
Best Pop: Lady Gaga
Best Alternative: Paramore
MTV EMA Global Icon: Bon Jovi
Best Rock: Thirty Seconds to Mars
Best Male: Justin Bieber
Best Video: Katy Perry 'California Gurls'
Best Hip Hop: Eminem
Free Your Mind: Shakira
Best Live: Linkin Park
Best Female: Lady Gaga
Best Song: Lady Gaga 'Bad Romance'
Best European Act: Marco Mengoni
Best Push Artist: Justin Bieber
World Stage: Tokio Hote