The guitarist married Amy White at an outdoor venue in his hometown surrounded by friends, family, bandmates and celebrity guests including comedian Noel Fielding, soccer star Peter Crouch and his wife Abbey Clancy.
After tying the knot, the bride and groom reportedly threw a wild party at their home, with further guests reportedly including One Direction's Louis Tomlinson and model Kate Moss.
The couple are parents to two boys, Ennio, five, and Lucio, three. The rocker previously told Q magazine that becoming a parent forced him to make the decision to quit drugs in 2011.
"I always write from home and I’ve just had a baby. I’m not going to be doing drugs around a little boy," the 35-year-old said. "There’s more at stake than music. When you’re getting up to do the milk in the morning, you don’t want to be out of your mind, do you?"
During an interview with the London Evening Standard in 2012, Serge was asked what the most romantic thing someone had ever done for him, and he replied, "My girlfriend (Amy) took me to a Mexican restaurant, El Camion in Soho. I love Mexican food and I am the taco king, so it was nice that someone found this place for me."