The former The Smiths star has worked with the two-piece before on their albums, and the trio will be coming together with the Royal Philharmonic Concert Orchestra for a special live performance at London's Royal Albert Hall on 2 April (17).
“We have often combined electronics with orchestrations on our records and now we’re going to do this in concert," the Pet Shop Boys said about the "very special night" in a statement. "Johnny has played on many of our albums and it will be a real thrill to have him on stage with us.
"The Teenage Cancer Trust is a wonderful organisation and we are delighted to be able to take part in this annual series of concerts which helps to fund their essential work.”
The Who frontman Roger Daltrey has been a longtime honorary patron of the Teenage Cancer Trust, which raises money for young people with cancer, and will help mark the 100th fundraising show by performing the band's 1969 rock opera Tommy in full for the first time in 27 years during two shows.
"All of these incredible musical moments are made even more special by the wonderful young people I have met over the past 17 years," Daltrey said in a statement. "They are young people first – cancer patients second. Their positivity and lust for life is such an inspiration to all of us who work with them and with the public’s help we aim to keep Teenage Cancer Trust leading the world in cancer care for these teenagers."
The line-up also includes headliners Paul Weller, British popstar Olly Murs and a night of comedy hosted by Romesh Ranganathan and featuring Jo Brand and Kevin Bridges. The gigs run from 27 March (17) to 2 April (17).