Comedian Jerry Seinfeld and Paul Simon are to team up to benefit a Los Angeles autism charity.

The odd couple will perform at One Night Only: A CONCERT FOR AUTISM SPEAKS at the end of September (05).

Seinfeld admits he felt compelled to do something about the disorder, which effects children's learning and communication skills after learning a friend had an autistic child.

He says, "There's something just particularly sad about the way it attacks children because they're fine for a couple of years and then all of a sudden they start to slip away."