The two stars will team up for The Comedian next year (16) with the producers behind Aniston's 2014 movie Cake.

In the film, De Niro will play an insult comic, who falls for Aniston's character at a wedding.

It's not the first time De Niro has tackled stand-up comedy onscreen - he played obsessed fan Rupert Pupkin opposite Jerry Lewis in 1982's The King of Comedy.

Reports suggest the actor has been trying to make the film for years.