The 46-year-old singer, who made his name in the pop band alongside Andrew Ridgeley in the 80s, claimed it would be impossible to re-capture the feel of the group 20 years later.
He said: "Wham! was about being young and exuberant and you can't recreate that feeling at a certain age.
"Andrew Ridgeley and I are still good friends but I'm afraid we'll never get back together. We both agree on that."
Although George is proud of the duo's legacy, there is one song he isn't keen on - their 1984 hit 'Wake Me Up Before You Go-Go'.
The 'Fastlove' singer said: "I'm not keen on that song. I haven't sung it for a long time."
As well as being unsure about some of the band's songs, George has previously confessed he made some fashion faux-pas while in Wham!.
He said: "When I see myself. I cringe mostly! Take the blonde hair. I wanted to have long, blond, straight hair because I didn't really want to be me.
"Looking back, I suppose I could have done without those curtain rings in my ears as well."