The 21-year-old Dj, who released his eponymous debut album last year (12), looks set to sweep the board at the industry event after receiving nods in categories including breakthrough artist, best male artist, best dance release, best Australian live act and best song.
He says, "It's amazing for me because most of this album I wrote in my bedroom at my parents' house. I'm very, very flattered."
Flume is also battling for the top prize, album of the year, against Nick Cave and The Bad Seeds (Push the Sky Away), Tame Impala (Lonerism), Guy Sebastian (Armageddon), and Birds Of Tokyo (March Fires).
In the best male category he will be up against Keith Urban, Guy Sebastian, Matt Corby and Paul Kelly, while fighting for the best female are Sarah Blasko, Missy Higgins, Jessica Mauboy, Emma Louise and Abbe May.
Best group nominees include Boy & Bear, Birds Of Tokyo, Empire Of The Sun, Nick Cave and The Bad Seeds and Tame Impala.
The prizegiving will take place at The Star Event Centre in Sydney on 1 December (13).