The singer and her band Florence and the Machine are up for four accolades at this year's ceremony but she admits while being in the running for prizes is "wonderful", it is also a "terrifying" prospect.
She told MTV News: "I'm still kind of processing it, to be honest. It's such an iconic event, and it's something I've watched on TV since I was a kid. It's one of those things, it's not real life, it's a dream scenario. So for me to be actually a part of it feels like I'm in some sort of parallel universe. It's kind of strange and wonderful and terrifying all at the same time."
Florence and the Machine are up for Best Rock Video, Best Art Direction, Best Cinematography and Video of the Year - for 'Dog Days Are Over' - at the VMAs.
The British singer has revealed the song 'Dog Days Are Over' started out with her and a friend banging pans in a cupboard.
Florence said: "I wrote 'Dog Days Are Over' in a closet with my friend Isabella Summers. We had no instruments, we banged our hands against the walls. We were using pans as instruments. We did it for fun, and then the video... I wanted it to be as artistic as possible. It wasn't about being pretty.
"I wanted something that was striking and made me look a bit scary, so for it to be recognised at something as huge as the VMAs is the most incredible thing, and I'm just really grateful for the opportunity to go. It's incredible."