Fellow musicians Charles Bradley and Jidenna will also feature in scenes set in the fictional Harlem, New York nightclub Paradise, run by villain Cornell Stokes, aka Cottonmouth, played by House of Cards star Mahershala Ali.
Showrunner Cheo Hodari Coker revealed the news during a show panel at the Television Critics Association over the weekend (29-31Jul16), joking, "We always said that God forbid the show doesn't work, at least we can book out the club.
Coker went on to share that each episode of Luke Cage has been named after tracks by Gang Starr, the influential rap duo formed by late MC Guru and DJ Premier.
"I'm calling episodes songs. They are all musical. Each episode is named after a Gang Starr song. For me, the reason for that was because I liken binge-watching to what used to happen back in the day when a record would come out, and if Prince released Lovesexy or Sign o' the Times, I would shut everything down and listen to the entire record, and the only time that we do that nowadays is with these shows.
"So the music kind of gives this undercurrent rhythm and it gives us a pulse for every single episode."
Luke Cage stars actor Mike Colter as the titular superhero, a former convict-turned-crimefighter. The show premieres on streaming service Netflix on 30 September (16).