The 'Not Afraid' rapper picked up nominations in the night's biggest categories, including Favourite Male Artist and Favourite Album in the Pop or Rock categories and Artist of the Year.
Eminem's five nominations are matched only by country group Lady Antebellum, who have nominations for Favourite Band in the Pop or Rock category and in a number of country categories.
British artists Sade and Taio Cruz have also picked up nominations, with Taio in the running for Breakthrough Artist and Sade having a nod in the Favorite Female Artist and favourite album in the Soul/R 'n' B categories.
Taio - who has had a number one single in the US with debut single 'Break Your Heart' - said of his nomination: "I was not expecting it at all, it was a massive surprise and it feels great to be out here and just recognised for the music I've made so far.
"We were surprised at the first single doing so well, just shocked with the second single doing as well as it's done. Now being nominated for an AMA is just as surprising."
The 2010 American Music Awards will be shown on Sunday, November 21. Winners are chosen by fans, who can vote online at ABC.com and AMAvote.com.
Full list of 2010 American Music Awards nominations
Favorite Male Artist, Pop or Rock
Favorite Female Artist, Pop or Rock
Favorite Band, Duo or Group, Pop or Rock
The Black Eyed Peas
Favorite Album, Pop or Rock
Justin Bieber - My World 2.0
Eminem - Recovery
Katy Perry - Teenage Dream
Favorite Male Artist, Country
Favorite Female Artist, Country
Favorite Band, Duo or Group, Country
Favorite Album, Country
Jason Aldean - Wide Open
Lady Antebellum - Need You Now
Carrie Underwood - Play On
Favorite Male Artist, Rap/Hip-Hop
Favorite Album, Rap/Hip-Hop
B.o.B. - B.o.B. Presents
Drake - Thank Me Later
Eminem - Recovery
Favorite Male Artist - Soul/R&B
Favorite Female Artist - Soul/R&B
Favorite Album, Soul/R&B
Alicia Keys - The Element of Freedom
Sade - Soldier of Love
Usher - Raymond v. Raymond
Favorite Album, Soundtracks
AC/DC - Iron Man 2
Glee: The Music, Volume 3 Showstoppers
The Twilight Saga: Eclipse
Favorite Artist, Alternative Rock Music
Favorite Artist, Adult Contemporary Music
Favorite Artist, Latin Music
Favorite Artist, Contemporary Inspirational
Artist of the Year
T-Mobile Breakthrough Artist Nominations
There's half of a great satire here, as Seth Rogen, James Franco and Evan Goldberg...
This lively and engaging documentary may be set out like an informercial, but it teaches...
Hip hop has always been more of a culture than just a genre of music....