The venue, one of London's biggest nightclubs, was shut down indefinitely in August (16) after two teenagers died after taking drugs bought inside the club, and its licence was suspended at the request of London's Metropolitan Police.
DJs and musicians such as Fatboy Slim made public pleas for it to be reopened but their lobbying didn't work and on Tuesday night (06Sep16) members of Islington Council licensing committee ordered the licence to be revoked permanently, claiming a "culture of drugs" exists in the club which management and security are "incapable of controlling".
The news of Fabric's closure has disappointed many musicians, with Ellie sharing the news on Twitter and adding a sad face emoji, and singer/songwriter Jessie Ware writing, "So sad about Fabric closing. Earliest clubbing memories and such an important club for london. #fabricreview."
British model Daisy Lowe simply wrote, "RIP Fabric" followed by a love heart emoji, while electronic duo Chase & Status called on Mayor of London Sadiq Khan to overturn the decision.
"Fabric losing its licence is an absolute disgrace," they tweeted. "@SadiqKhan you must get this overturned. There's nowhere left in London.. Our culture has been torn apart with the closing of @fabriclondon & every club with serious history & importance in London #FabricReview... Left in the hands of these people with the power to revoke licences but who have no real understanding of the topic or culture, it's archaic."
BBC radio DJs MistaJam, Nick Grimshaw and Lauren Laverne, formerly of pop Kenickie, also expressed their sadness, while the hashtag #SaveFabric began circulating on Twitter.
A spokesman for the club said they were "extremely disappointed" in the decision, which sets a "troubling precedent" for clubs and won't solve the drug problem. Supporters of the club are calling for an appeal.